Introduction of a tailor made anion receptor into the side chain of small peptides allows fine-tuning the thermodynamic signature of peptide-DNA binding.
نویسندگان
چکیده
The binding between peptides and DNA is often driven by entropic forces. We demonstrate herein a new approach to shift the thermodynamic profile of peptide/DNA binding from entropy to enthalpy driven. This eventually leads to higher compacted DNA aggregates which are important for gene transfection.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 14 37 شماره
صفحات -
تاریخ انتشار 2016